Trivalent Attenuated Cold-Adapted Influenza Virus Vaccine: Reduced Viral Shedding and Serum Antibody Responses in Susceptible Adults
Identifieur interne : 001E61 ( Main/Exploration ); précédent : 001E60; suivant : 001E62Trivalent Attenuated Cold-Adapted Influenza Virus Vaccine: Reduced Viral Shedding and Serum Antibody Responses in Susceptible Adults
Auteurs : Wendy A. Keitel [États-Unis] ; Robert B. Couch ; John M. Quarles ; Thomas R. Cate ; Barbara Baxter ; Hunein F. MaassabSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1993.
Abstract
Trivalent cold-adapted recombinant (CR) influenza virus vaccines containing types A (H1N1 and H3N2) and Bviruses were evaluated in two double-blind, placebo-controlled trials. Susceptible adults were randomly assigned to receive the following vaccines by intranasal drops 1 month apart: two doses of trivalent vaccine, bivalent CR influenza A (Bi A) vaccine followed by monovalent B (Mono B) vaccine or vice versa, or two doses of placebo. All vaccines were well tolerated. Shedding of each of the three vaccine viruses was reduced after the first dose of trivalent vaccine compared with primary vaccination with Bi A or Mono B. Shedding was also reduced after second vaccinations, whether homologous (trivalent-trivalent) or heterologous (Bi A/Mono B or Mono B/Bi A). Reduced viral shedding was associated with reduced serum antibody responses. Thus, both simultaneous and sequential inoculations of susceptible adults with CR influenza vaccine viruses result in reduced viral shedding and serum antibody responses.
Url:
DOI: 10.1093/infdis/167.2.305
Affiliations:
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Keitel</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Wendy Anne Keitel, Acute Viral Respiratory Diseases Unit, Department of Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. Couch</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Quarles, John M" sort="Quarles, John M" uniqKey="Quarles J" first="John M." last="Quarles">John M. Quarles</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Baxter, Barbara" sort="Baxter, Barbara" uniqKey="Baxter B" first="Barbara" last="Baxter">Barbara Baxter</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name><affiliation><wicri:noCountry code="subField">Arbor</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1993-02">1993</date><biblScope unit="vol">167</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="305">305</biblScope><biblScope unit="page" to="311">311</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Trivalent cold-adapted recombinant (CR) influenza virus vaccines containing types A (H1N1 and H3N2) and Bviruses were evaluated in two double-blind, placebo-controlled trials. Susceptible adults were randomly assigned to receive the following vaccines by intranasal drops 1 month apart: two doses of trivalent vaccine, bivalent CR influenza A (Bi A) vaccine followed by monovalent B (Mono B) vaccine or vice versa, or two doses of placebo. All vaccines were well tolerated. Shedding of each of the three vaccine viruses was reduced after the first dose of trivalent vaccine compared with primary vaccination with Bi A or Mono B. Shedding was also reduced after second vaccinations, whether homologous (trivalent-trivalent) or heterologous (Bi A/Mono B or Mono B/Bi A). Reduced viral shedding was associated with reduced serum antibody responses. Thus, both simultaneous and sequential inoculations of susceptible adults with CR influenza vaccine viruses result in reduced viral shedding and serum antibody responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Baxter, Barbara" sort="Baxter, Barbara" uniqKey="Baxter B" first="Barbara" last="Baxter">Barbara Baxter</name><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. Couch</name><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name><name sortKey="Quarles, John M" sort="Quarles, John M" uniqKey="Quarles J" first="John M." last="Quarles">John M. Quarles</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Keitel, Wendy A" sort="Keitel, Wendy A" uniqKey="Keitel W" first="Wendy A." last="Keitel">Wendy A. Keitel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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